Mike Monteiro, writing at .net:
We have more processing power, affordable tools, and combined intelligence right this very minute than at any point in the history of design. We are using it to build shit. It’s time to aim higher. Let’s find problems to solve that actually improve people’s lives.
Most of the resolutions on this list can be applied to almost any occupation, not just graphic design. Think about what you are working on, does it have any real meaning? What are you contributing to society? Do you care about your work?
I'm not saying that I'm an authority on the topic, because I'm far from it. I do, however, think about what I'm contributing and what I'm getting out of it in return (that's not necessarily monetary compensation). If something isn't clicking then it's probably time to make a change.